Throughout the 17th and 18th centuries, two schools of thought dominated philosophical inquiry: Continental Rationalism and British Empiricism. This paper will be concerned with comparing a representative from each school, Rene Descartes and David Hume, respectively. Although each philosopher built upon a different epistemological foundation, the philosophy of each is marked by skepticism, arbitrariness, and presuppositional inconsistency. Neither allows his philosophy to be founded upon and shaped by the self-attesting Word of God. Three key thrusts in their philosophy will be compared: epistemological method, substance and interaction, and the existence of God.